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KMID : 1123920020160051055
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 5 p.1055 ~ p.1059
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Effect of Liuweidihuang-tang on Alcohol-induced Decrease in New Cell Formation in Rat Dentate Gyrus
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Bahn Goon-Ho
Yoon Doh-Joon
Park Jin-Kyung
Lee Taeck-Hyun
Jang Mi-Hyoon
Shin Min-Chul
Kim Chang-Ju
Paik Eun-Kyung
Park Jae-Hyung
Cho Son-Hae
Lee Choong-Yool
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Abstract
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Liuweidihuang-tang has been traditionally used for the treatment of delayed mental and physical development in children, complications of diabetes. and glomerulonephritis. In the present study, the effect of Liuweidihuang-tang on cell proliferation in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats was investigated via 5-bromo-2’ -deoxyuridine (BrdU) immunohistochemistry. Alcohol administration was shown to decrease the number of BrdU-positive cells in the dentate gyrus, while Liuweidihuang-tang treatment increased new cell formation in the dentate gyrus under normal conditions and alcohol intoxication. It was thus demonstrated that aqueous extract of Liuweidihuang-tang exerts a protective effect against alcohol-induced decrease in new cell formation.
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KEYWORD
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Liuweidihuang-tang, alcohol, 5-bromo-2’-deoxyuridine, dentate gyrus, immunohistochenmistry, cell proliferation
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